social/scientific debate arose in psychiatry, as in the case of medico-legal disputes over individual responsibility in property laws, the Enlightenment project of civilising the les enfants sauvage as a means of exploring human potentials, and the racial politics of Social Darwinism that gave rise to the notorious term ‘Mongolism’. By unveiling the complex and sometimes tragic family history of John Langdon Down

In the age of prenatal screening and early intervention even at the molecular level, much has been said about the politics of geneticisation, yet relatively little remains known about how this politics actually shapes people's experiences. In this exquisite book about the history of Downs syndrome, which won the 2013 Dingle Prize by the British Society for the History of Science, Wright shows us how people influenced by genetic self-knowledge and their families have come to creatively reshape their identities, and in the process, transform popular and scientific assumptions about the boundaries of human nature. Wright's account makes it clear that one can re-read the history of psychiatry with a refreshingly new perspective through the lens of Downs. Downs seem to have always been there whenever a new crucial social/scientific debate arose in psychiatry, as in the case of medico-legal disputes over individual responsibility in property laws, the Enlightenment project of civilising the les enfants sauvage as a means of exploring human potentials, and the racial politics of Social Darwinism that gave rise to the notorious term 'Mongolism'. By unveiling the complex and sometimes tragic family history of John Langdon Down and his descendants and the Catholic crusade of Jérôme Lejeune (whose status as the discoverer of trisomy 21 is now in dispute), Wright fully explores the moral ambiguities of science, with which heroic attempts to help the disabled have at times unwittingly inflicted suffering on those who were meant to be saved. Indeed, the most striking aspect of the history of Downs is the bitter fruit of genetic science: the discovery of trisomy 21 has made the public more sympathetic and accepting of those born with this disability, yet this very technology has made it almost possible to eradicate them through prenatal screening. Wright's account also demonstrates that, despite the seeming universality of Downs, the images and actual experiences of it have been diverse, shaped as much by local politics of difference as by scientific knowledge. While the initial genetic discovery helped de-stigmatise Downs, it also gave rise to debates in bioethics about whether to withdraw life-saving measures for babies born with this disability. Documenting the era of institutionalisation and subsequent patient activism, Wright shows how people with Downs have been at the forefront of questioning cerebral subjectivity. Today, people with Downs are more visible than ever in the community; they go to college, get married, get a job, …